MA-5 Mitochonic Acid

Scientists at Tohoku University, Japan have tested a number of synthetic chemicals using cell cultures representing the major Mitochondrial disorders.  Their tests show if the cells increase their production of ATP, the cell “fuel”, and if the cells survive when given chemicals which inhibit the mitochondria even more.

Mitochonic Acid 5 (MA-5,  full chemical name  4-(2,4-difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid) made the cells increase production of ATP and more cells survived when mitochondria were inhibited. (26118651)

MA-5 is derived from the plant growth hormone Indole-3-acetic acid,

The study tested cells representing Leigh Syndrome, MELAS, Leber Hereditary Optic Neuropathy and Kearns-Sayre Syndrome.

This is only a laboratory experiment and may not lead to a therapy, but does show that MA-5 is worth testing.

This page was last updated August 12 2015

 

 

 

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